Ribosomal protein L4



Ribosomal protein L4 (RPL4 ) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It may actively participate in the catalysis of peptide bond formation. In the archaea like in Haloarcula marismortui the L4 is called L4P (RPL4P). The images at the left and at the right correspond to one representative RPL4, i.e. the crystal structure of Ribosomal protein L4 from Thermus thermophilus (2xg0, chain F).

3D Structures of Ribosomal protein L4
Update June 2011

RPL4
1dmg – RPL4 – Thermotoga maritima

L4 in 50S subunit+RNA
2xg0, 2xg2, 3kir, 3kit, 3kiw, 3kiy – TtRPL4 in 50S subunit+RNA fragments – Thermus thermophilus

2x9s, 2x9u, 3kni, 3knk, 3knm, 3kno, 2wrj, 2wrl, 2wro, 2wrr, 3hux, 3huz, 2wh2, 2wh4, 2wdi, 2wdj, 2wdl, 2wdn, 1vsp, 2v47, 2v49, 1vsa, 2hgj, 2hgq, 2hgu, 2j01, 2j03, 1yl3, 3mrz, 3ms1, 3i8f, 3i8i, 3i9c, 3i9e, 3f1f, 3f1h, 3d5b, 3d5d, 2b66, 2b9n, 2b9p, 1giy, 2y0v, 2y0x, 2y0z, 2y11, 2y13, 2y15, 2y17, 2y19, 3pyo, 3pyr, 3pyt, 3pyv -  TtRPL4 in 50S subunit+5S RRNA+23S RRNA

3fin - TtRPL4 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM

2wwq – EcRPL4 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – Escherichia coli

3i1n, 3i1p, 3i1r, 3i1t, 3i20, 3i22, 3e1b, 3e1d, 3df2, 3df4, 2vhn, 2qov, 2qox, 2i2t, 2i2v, 1vs6, 1vs8, 2aw4, 2awb, 3ofd, 3og0, 1vor 1vou, 1vow, 1voy, 1vp0, 1pnu, 1pny, 3r8s, 3r8t - EcRPL4 in 50S subunit+5S RRNA+23S RRNA

3fik, 2gya, 2gyc, 3bbx, 1p85, 1p86, 3izt, 3izu - EcRPL4 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM

3kcr - EcRPL4 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase

3j01 – EcRPL4 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase – Cryo-EM

2rdo - EcRPL4 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM

3bbo – RPL4 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach

3iy9 – RPL4  in 50S subunit – Leishmania taretolae

2zjq, 2zjr, 1nkw - DrRPL4 in 50S subunit+5S RRNA+23S RRNA – Deinococcus radiodurans

1kqs - HmRPL4P in 50S subunit+5S RRNA+23S RRNA+CCA - Haloarcula marismortui

1jj2, 1ffk, 3cc2, 2qa4 - HmRPL4P in 50S subunit+5S RRNA+23S RRNA

3cc7, 3cce, 3ccj, 3ccl, 3ccm, 3ccq, 3ccr, 3ccs, 3ccu, 3ccv - HmRPL4P in 50S subunit+5S RRNA+23S RRNA (mutant)

L4 in 50S subunit + antibiotics
3dll, 2zjp, 3cf5, 1xbp, 1sm1, 1nwx, 1nwy, 3pio, 3pip - DrRPL4 in 50S subunit+5S RRNA+23S RRNA+antibiotic

3oh5, 3oh7, 3ohj, 3ohk, 3ohz, 3oi1, 3oi3, 3oi5 – TtRPL4 in 50S subunit+5S RRNA+23S RRNA+antibiotic

2qam, 2qao, 2qoz, 2qp1, 2qba, 2qbc, 3ofc, 3ofz, 3ofq, 3ofr, 1vt2, 3orb, 3oas, 3oat - EcRPL4 in 50S subunit+5S RRNA+23S RRNA+antibiotic

1k73, 1kc8, 1k8a, 1k9m, 1kd1, 1m1k, 3i55, 3i56, 3g4s, 3g6e, 3g71, 2qex, 3cpw,3cc4, 3cd6, 2otj, 2otl, 3cxc - HmRPL4P in 50S subunit+5S RRNA+23S RRNA+antibiotic - Halobacterium marismortui

1m90, 3cma, 3cme - HmRPL4P in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin

1jzx, 1jzy, 1jzz, 1j5a, 1k01 - DrRPL4+RPL22+RPL42+23S RRNA+antibiotic

L4 in 60S subunit
3jyw - RPL4 in 60S subunit – Thermomyces lanuginosus – Cryo-EM

2ftc - RPL4 in 60S subunit+16S RRNA - bovine

1s1i - yRPL4 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast

3o58, 3o5h – yRPL4 in 60S subunit+25S RRNA+5SRRNA+5.8RRNA

2ww9, 2wwa, 2wwb – yRPL4+RPL17+RPL19+RPL15+RPL25+RPL26+RPL41+RPL45+RPL49+25S RRNA+SSH1P+SSS1+SEB2

L4 in large + small ribosomal subunit
1ml5 - EcRPL4 in 50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – EM

2zkr - RPL4 in 60S ribosomal subunit+30S ribosomal subunit+28S RRNA+5.8S RRNA – Cryo-EM - dog

L4 in 50S subunit + ribosome releasing factor (RRF)
2qbe, 2qbg, 2qbi, 2qbk, 2z4l, 2z4n - EcRPL4 in 50S subunit+5S RRNA+23S RRNA+RRF

L4 in 50S subunit + various proteins
2vhm - EcRPL4 in 50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix

2j28 - EcRPL4 in 50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM

1w2b - HmRPL4P in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal